Search Result

Pathways Recommended:	NF-κB

Results for "

NF-κB transcriptional

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (25) Acyltransferase (11) Akt (1) AP-1 (1) Apoptosis (8) Autophagy (6) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (2) CDK (2) COX (8) CXCR (1) Cytochrome P450 (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (5) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (1) Ferroptosis (1) Glucocorticoid Receptor (1) Histone Acetyltransferase (1) IKK (3) Influenza Virus (1) Interleukin Related (1) Keap1-Nrf2 (3) Mitophagy (4) MyD88 (1) NO Synthase (3) p38 MAPK (1) Proteasome (1) Ribosomal S6 Kinase (RSK) (1) Sirtuin (1) STAT (1) TNF Receptor (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (4) Inflammation/Immunology (43) Metabolic Disease (2) Neurological Disease (1)

By Targets:

NF-κB (25)

Acyltransferase (11)

Akt (1)

AP-1 (1)

Apoptosis (8)

Autophagy (6)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Calcium Channel (2)

CDK (2)

COX (8)

CXCR (1)

Cytochrome P450 (2)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (5)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (1)

Ferroptosis (1)

Glucocorticoid Receptor (1)

Histone Acetyltransferase (1)

IKK (3)

Influenza Virus (1)

Interleukin Related (1)

Keap1-Nrf2 (3)

Mitophagy (4)

MyD88 (1)

NO Synthase (3)

p38 MAPK (1)

Proteasome (1)

Ribosomal S6 Kinase (RSK) (1)

Sirtuin (1)

STAT (1)

TNF Receptor (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (4)

Inflammation/Immunology (43)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: NF-κB

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19498

WAY-204688 SIM-688
WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of *NF-κB* transcriptional activity with an IC₅₀ of 122 ± 30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.

HY-13982

JSH-23 Maximum Cited Publications 80 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an *NF-κB* inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-P1832A

PTD-p65-P1 Peptide TFA 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-144745

HSR1304	NF-κB	Cancer
HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases .

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-133987

AP-1/NF-κB activation inhibitor 1 1 Publications Verification	NF-κB	Inflammation/Immunology
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and *NF-κB* mediated transcriptional activation inhibitor (IC₅₀=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells .

HY-10172

IMD-0354 10+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-14645A

(+)-DHMEQ 2 Publications Verification (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ	Keap1-Nrf2	Inflammation/Immunology
(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

HY-119970

Helenalin 4 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-139024

ACAT-IN-7

Acyltransferase Inflammation/Immunology

ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription .
HY-139020

ACAT-IN-3

Acyltransferase Inflammation/Immunology

ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription .

ACAT-IN-7	Acyltransferase	Inflammation/Immunology
ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription .

ACAT-IN-3	Acyltransferase	Inflammation/Immunology
ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-10072

SPC 839

NF-κB AP-1 Inflammation/Immunology

SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC₅₀ of 0.008 μM .

SPC 839	NF-κB AP-1	Inflammation/Immunology
SPC 839 (compound 10) is an orally active inhibitor of AP-1 and *NF-kB* mediated transcriptional activation with IC₅₀ of 0.008 μM .

HY-139021

ACAT-IN-4	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 inhibits NF-κB mediated transcription .

HY-139022

ACAT-IN-5	Acyltransferase	Inflammation/Immunology
ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription .

HY-139025

ACAT-IN-8	Acyltransferase	Inflammation/Immunology
ACAT-IN-8 (example 206) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-8 inhibits NF-κB mediated transcription .

HY-139021A

ACAT-IN-4 hydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription .

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively .

HY-N4182

Licochalcone E	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-117726

WAY-169916	Estrogen Receptor/ERR NF-κB	Inflammation/Immunology
WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity. WAY-169916 has potent anti-inflammatory effect .

HY-N1196

Suberosin
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors *NF-AT* and *NF-κB* .

HY-N0907

Ginsenoside Rg6	NF-κB Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rg6 inhibits TNF-α-induced *NF-κB* transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d₆	COX Autophagy Mitophagy Apoptosis	Inflammation/Immunology Cancer
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-142100

Licoagrochalcone C	NF-κB	Inflammation/Immunology
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on *NF-κB* transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production .

HY-13812

QNZ 30+ Cited Publications EVP4593	NF-κB TNF Receptor	Neurological Disease Inflammation/Immunology
QNZ (EVP4593) shows strong inhibitory effects on *NF-κB* transcriptional activation and TNF-α production with IC₅₀s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.

HY-139019

ACAT-IN-2	Acyltransferase	Inflammation/Immunology
ACAT-IN-2 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 187. ACAT-IN-2 inhibits NF-κB mediated transcription .

HY-139026

ACAT-IN-9	Acyltransferase	Inflammation/Immunology
ACAT-IN-9 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 207. ACAT-IN-9 inhibits NF-κB mediated transcription .

HY-139027

ACAT-IN-10	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription .

HY-139027A

ACAT-IN-10 dihydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription .

HY-139023

ACAT-IN-6	Acyltransferase	Inflammation/Immunology
ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription .

HY-N11994

Aloeresin G	TNF Receptor	Inflammation/Immunology
Aloeresin G is a chromone glycoside that can be isolated from Aloe. Aloeresin G has a weak inhibitory effect on TNFα-induced NF-κB transcriptional activity, with an IC 50 value of 40.02 μM .

HY-N0906

Ginsenoside Rk3	NF-κB	Cardiovascular Disease Inflammation/Immunology
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced *NF-κB* transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-N11892

7-O-Methylaloesinol	NF-κB	Others
7-O-Methylaloesinol is a chromone derivative. 7-O-Methylaloesinol shows significant inhibitory effects against TNFα-induced NF-κB transcriptional activity with an IC₅₀ value of 29.07 μM .

HY-112671

CDDO-dhTFEA RTA dh404	Keap1-Nrf2 NF-κB	Inflammation/Immunology
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor *NF-κB* . CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats .

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-B0167R

Salicylic acid (Standard) 2-Hydroxybenzoic acid (Standard)	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (Standard) is the analytical standard of Salicylic acid. This product is intended for research and analytical applications. Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N11996

Aloenin aglycone	NO Synthase NF-κB	Others
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-110261

GS143	IKK E1/E2/E3 Enzyme NF-κB	Inflammation/Immunology
GS143 is a selective IκBα ubiquitination inhibitor with an IC₅₀ of 5.2 μM for SCF ^βTrCP1-mediated IκBα ubiquitylation. GS143 suppresses *NF-κB* activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .

HY-50937

ST 2825 60+ Cited Publications	MyD88	Inflammation/Immunology
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity .

HY-15681

Senexin A 5+ Cited Publications	CDK	Cancer
Senexin A is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-15681A

Senexin A hydrochloride	CDK	Cancer
Senexin A hydrochloride is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-N0279

Cardamonin 5+ Cited Publications Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, *NF-κB, Akt, STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective AP-1 transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model .

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Inflammation/Immunology Cancer
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced *NF-κB* transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N1445

Isoquercetin 1 Publications Verification Quercetin 3-glucoside
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-146564

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the *NF-κB* mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) .

HY-124056

AZ10397767	CXCR	Cancer
AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC₅₀ of 1 nM. AZ10397767 attenuates the Oxaliplatin (HY-17371)-induced NF-κB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo .

HY-146561

S-HP210	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells .

HY-156297

β5i-IN-1	Proteasome	Inflammation/Immunology
β5i-IN-1 is a potent and selective inhibitor of β5i with a IC₅₀ of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of *NF-κB*. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis .

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

805 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 805 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

HY-L090

Transcription Factor-Targeted Library

1288 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1288 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Category	Target	Chemical Structure